FAM120A

Across TCGA patient cohorts, FAM120A mutation is significantly associated with the RNA expression of many other genes, with 5,353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM120A-associated genes across cancer lineages are PSMB6, RN7SL712P, and MMP12. Each is linked with FAM120A in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM120A-to-partner and partner-to-FAM120A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by FAM120A-low versus FAM120A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM120A→partner) and Y-score (partner→FAM120A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMB6 →	+0.458	+1.688	<.001	<.001	3	4
SKCM	RN7SL712P →	+0.067	+4.049	<.001	.007	3	3
UCEC	MMP12 →	+1.042	+1.480	<.001	.006	3	3
UCEC	POLE2 →	+0.585	+1.699	<.001	<.001	3	3
UCEC	GSKIP →	+0.601	+2.087	<.001	<.001	3	3
UCEC	SMS →	+0.600	+2.467	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,353 associations by consensus.

PSMB6 by FAM120A expression — UCEC

Explore this box plot interactively →