FAM120A

Across TCGA pan-cancer cohorts, FAM120A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM120A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM120A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM120A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where FAM120A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM120A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.951	<.001	11	view →
LIHC	All	II,III,IV	+0.733	<.001	9	view →
BRCA	All	III,IV	+0.699	<.001	8	view →
LUSC	Female	All	+0.641	<.001	7	view →
LUAD	Male	All	+0.469	<.001	7	view →
STAD	Male	II,III,IV	+1.097	<.001	6	view →
CHOL	Male	All	+1.378	<.001	4	view →
ESCA	All	All	+1.022	.008	4	view →
KIRP	Female	II,III,IV	+0.487	.023	3	view →
THCA	All	All	−0.198	.012	3	view →
KICH	All	All	−0.511	.009	2	view →
PAAD	Male	All	+0.510	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM120A–HNSC

Open the HNSC breakdown →