matrix metallopeptidase 12Genealiases: HME · ME · MME · MMP-12
Q-omics provides the consensus-scored MMP12 profile across patient tissues and cancer cell-line models. MMP12 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, MMP12 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, MMP12 protein abundance shows 14,891 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight UVM, HNSC, and LUAD as cancer lineages where MMP12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MMP12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MMP12 survival associations across molecular data types. MMP12 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (7) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MMP12 RNA expression–survival associations across cancer types. High MMP12 expression shows unfavorable associations in UVM, ACC, KIRP, KIRC and LUSC, but favorable associations in COAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for MMP12 RNA expression.
This table summarizes MMP12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MMP12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MMP12 shows higher tumor expression in HNSC, LUAD, THCA, LUSC, STAD and COAD. The HNSC box plot shows higher MMP12 RNA expression in tumor versus normal tissue (log2 FC = +4.417, t-test p < 0.001).
This table shows molecular features associated with MMP12 in patient tissues and cancer cell lines. In patient samples, MMP12 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, MMP12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
