MMP12

Across TCGA cell cohorts, MMP12 RNA expression is significantly associated with the go_rna of many other GO terms, with 337 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible MMP12-associated GO terms across cancer lineages are Regulation of protein monoubiquitination, Positive regulation of protein monoubiquitination, and Regulation of IRE1-mediated unfolded protein response. Each is linked with MMP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMP12-to-partner and partner-to-MMP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein monoubiquitination grouped by MMP12-low versus MMP12-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP12→partner) and Y-score (partner→MMP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of protein monoubiquitination →	+0.061	+0.272	.009	.005	3	3
CNS	Positive regulation of protein monoubiquitination →	+0.061	+0.272	.009	.005	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of IRE1-mediated unfolded protein response →	+0.150	+1.077	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	Negative regulation of actin filament depolymerization →	+0.172	+0.651	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	Host-mediated suppression of symbiont invasion →	+0.084	+0.639	.005	.004	3	3
UPPER_AERODIGESTIVE_TRACT	Actin filament capping →	+0.130	+0.872	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

Regulation of protein monoubiquitination by MMP12 expression — CNS

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