MMP12

Across TCGA patient cohorts, MMP12 mutation is significantly associated with the RNA expression of many other genes, with 2,056 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP12-associated genes across cancer lineages are MIR597, MIR7845, and RNU6-1316P. Each is linked with MMP12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP12-to-partner and partner-to-MMP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR597 grouped by MMP12-low versus MMP12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP12→partner) and Y-score (partner→MMP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR597 →	+0.359	+5.038	<.001	.009	3	3
LIHC	MIR7845 →	+0.288	+4.268	<.001	.001	3	2
HNSC	RNU6-1316P →	+0.380	+4.425	.002	.006	3	2
HNSC	TRAJ14 →	+0.813	+5.182	<.001	.001	3	2
HNSC	RNA5SP213 →	+0.268	+6.132	<.001	.001	3	2
HNSC	RN7SL865P →	+0.109	+4.655	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,056 associations by consensus.

MIR597 by MMP12 expression — BLCA

Explore this box plot interactively →