MMP12

Across TCGA patient cohorts, MMP12 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP12-associated genes across cancer lineages are Rad50, Annexin-1, and 4E-BP1. Each is linked with MMP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP12-to-partner and partner-to-MMP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MMP12-low versus MMP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP12→partner) and Y-score (partner→MMP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.202	-1.662	.018	.011	3	2
UCEC	Annexin-1 →	+0.457	+2.321	.014	.033	3	2
SKCM	4E-BP1 →	+0.360	+2.321	.010	.033	3	2
UCEC	EGFR →	-0.146	-1.848	.009	.049	3	1
UCEC	eIF4G →	+0.235	+2.000	.032	.003	3	1
UCEC	FASN →	+0.282	+1.700	.043	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Rad50 by MMP12 expression — UCEC

Explore this box plot interactively →