MMP12

Across TCGA pan-cancer cohorts, MMP12 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MMP12 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MMP12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP12 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

PDAC, LUAD, and COAD are the cancer types where MMP12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.667	0.985	.009	25	view →
LUAD	OS	Median	II,III,IV	0.337	0.908	.002	19	view →
COAD	DFS	Median	IV	0.565	1.000	.028	18	view →
HNSC	DFS	Median	All	0.331	0.871	.018	4	view →
LSCC	OS	Quartile	All	1.000	0.916	.038	4	view →
CCRCC	OS	Median	All	0.646	1.000	.038	3	view →
GBM	OS	Quartile	All	1.000	0.717	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MMP12–PDAC (OS)

Open the PDAC breakdown →