FAM120A

Across TCGA pan-cancer cohorts, FAM120A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM120A data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM120A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM120A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where FAM120A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.972	0.167	.006	27	view →
COAD	DFS	Tertile	All	1.000	0.883	.040	24	view →
LUAD	OS	Tertile	All	1.000	0.923	.017	6	view →
PDAC	DFS	Quartile	III,IV	0.969	0.219	.006	5	view →
LSCC	OS	Median	All	0.773	1.000	.029	3	view →
GBM	DFS	Median	All	0.656	0.772	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FAM120A–CCRCC (DFS)

Open the CCRCC breakdown →