cyclin D binding myb like transcription factor 1Genealiases: DMP1 · DMTF · MRUL · hDMP1
Q-omics provides the consensus-scored DMTF1 profile across patient tissues and cancer cell-line models. DMTF1 expression is associated with patient survival in 30 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, DMTF1 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, DMTF1 RNA expression shows 21,166 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KICH, HNSC, and UVM as cancer lineages where DMTF1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DMTF1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DMTF1 survival associations across molecular data types. DMTF1 RNA expression shows survival associations in the most cancer types (30), followed by mutation status (4) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DMTF1 RNA expression–survival associations across cancer types. High DMTF1 expression shows unfavorable associations in KICH, KIRC, ACC, LGG and LIHC, but favorable associations in SKCM. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KICH as the clearest survival context for DMTF1 RNA expression.
This table summarizes DMTF1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for DMTF1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DMTF1 shows lower tumor expression in KICH and higher tumor expression in HNSC, KIRC, LIHC, BLCA and CHOL. The HNSC box plot shows higher DMTF1 RNA expression in tumor versus normal tissue (log2 FC = +1.048, t-test p < 0.001).
This table shows molecular features associated with DMTF1 in patient tissues and cancer cell lines. In patient samples, DMTF1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, DMTF1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
