DMTF1

Across TCGA cell cohorts, DMTF1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMTF1-associated genes across cancer lineages are GPR101, KLHL40, and OR2AK2. Each is linked with DMTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMTF1-to-partner and partner-to-DMTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by DMTF1-low versus DMTF1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMTF1→partner) and Y-score (partner→DMTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GPR101 →	+0.020	+5.087	<.001	.004	3	1
OVARY	KLHL40 →	+0.011	+4.450	<.001	.004	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
OVARY	OR11H2 →	+0.073	+4.450	<.001	.004	3	1
OVARY	OR13C2 →	+0.068	+4.228	<.001	.006	3	1
LARGE_INTESTINE	PLA2G3 →	+1.112	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

GPR101 by DMTF1 expression — URINARY_TRACT

Explore this box plot interactively →