olfactory receptor family 2 subfamily AK member 2Genealiases: OR1-47 · OR2AK1P
Q-omics provides the consensus-scored OR2AK2 profile across patient tissues and cancer cell-line models. OR2AK2 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, OR2AK2 is differentially expressed in 2, with the highest sampling consensus in KIRC. Additionally, OR2AK2 RNA expression shows 9,619 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight MESO, KIRC, and LAML as cancer lineages where OR2AK2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR2AK2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR2AK2 survival associations across molecular data types. OR2AK2 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR2AK2 RNA expression–survival associations across cancer types. High OR2AK2 expression shows unfavorable associations in MESO, DLBC, UCEC, LUSC, THCA and BRCA. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for OR2AK2 RNA expression.
This table summarizes OR2AK2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for OR2AK2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR2AK2 shows lower tumor expression in THCA and higher tumor expression in KIRC. The KIRC box plot shows higher OR2AK2 RNA expression in tumor versus normal tissue (log2 FC = +0.012, t-test p = .012).
This table shows molecular features associated with OR2AK2 in patient tissues and cancer cell lines. In patient samples, OR2AK2 shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set. In cancer cell lines, OR2AK2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in BONE and BREAST.
