DMTF1

Across TCGA pan-cancer cohorts, DMTF1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DMTF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DMTF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DMTF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where DMTF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DMTF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.048	<.001	12	view →
KIRC	All	All	+0.420	<.001	10	view →
LIHC	Female	II,III,IV	+1.049	<.001	8	view →
KICH	Female	All	−1.238	<.001	7	view →
BLCA	All	All	+0.539	.006	6	view →
CHOL	Male	All	+2.173	<.001	5	view →
COAD	All	II,III,IV	+0.399	.001	4	view →
KIRP	All	IV	+1.020	.018	2	view →
ESCA	All	All	+0.643	.004	2	view →
THCA	All	II,III,IV	−0.423	.020	2	view →
UCEC	All	All	−0.320	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DMTF1–HNSC

Open the HNSC breakdown →