DMTF1

Across TCGA patient cohorts, DMTF1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMTF1-associated genes across cancer lineages are JNK2, mTOR_pS2448, and Notch1. Each is linked with DMTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMTF1-to-partner and partner-to-DMTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DMTF1-low versus DMTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMTF1→partner) and Y-score (partner→DMTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.201	+1.916	.001	.009	3	2
UCEC	mTOR_pS2448 →	-0.129	-1.986	.005	.008	3	2
UCEC	Notch1 →	+0.162	+2.515	<.001	<.001	3	2
UCEC	beta-Catenin →	+0.336	+1.353	.035	.015	3	2
UCEC	14-3-3_beta →	-0.080	-1.651	.011	.019	3	1
UCEC	eEF2 →	+0.271	+2.115	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK2 by DMTF1 expression — UCEC

Explore this box plot interactively →