CXADR cell adhesion moleculeGenealiases: CAR · CAR4/6 · HCAR
Q-omics provides the consensus-scored CXADR profile across patient tissues and cancer cell-line models. CXADR expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CXADR is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, CXADR protein abundance shows 20,995 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight HNSC, KICH, and LUAD as cancer lineages where CXADR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CXADR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CXADR survival associations across molecular data types. CXADR RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CXADR RNA expression–survival associations across cancer types. High CXADR expression shows unfavorable associations in THCA and LGG, but favorable associations in HNSC, COAD, STAD and LUSC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for CXADR RNA expression.
This table summarizes CXADR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for CXADR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CXADR shows lower tumor expression in KICH and KIRC and higher tumor expression in BLCA, UCEC, LIHC and LUSC. The KICH box plot shows higher CXADR RNA expression in normal versus tumor tissue (log2 FC = −2.812, t-test p < 0.001).
This table shows molecular features associated with CXADR in patient tissues and cancer cell lines. In patient samples, CXADR shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, CXADR RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
