CXADR

Across TCGA patient cohorts, CXADR mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXADR-associated genes across cancer lineages are Ku80, PCNA, and STAT3_pY705. Each is linked with CXADR in more than 1 cancer types. Because this analysis shows association rather than direction, both CXADR-to-partner and partner-to-CXADR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CXADR-low versus CXADR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXADR→partner) and Y-score (partner→CXADR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.249	+1.710	.004	.025	3	2
UCEC	PCNA →	+0.202	+1.847	.010	.008	3	2
UCEC	STAT3_pY705 →	-0.388	-2.311	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.116	-3.432	.001	.005	3	1
UCEC	EGFR →	-0.188	-1.502	.001	.030	3	1
UCEC	eIF4E →	+0.172	+1.847	.026	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Ku80 by CXADR expression — UCEC

Explore this box plot interactively →