CXADR

Across TCGA pan-cancer cohorts, CXADR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CXADR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CXADR RNA is repressed in tumor relative to normal tissue. In most cancer types CXADR is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and BLCA are the cancer types where CXADR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXADR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−2.812	<.001	11	view →
KIRC	Female	All	−1.272	<.001	11	view →
BLCA	All	III,IV	+2.355	.003	7	view →
UCEC	All	All	+1.764	<.001	6	view →
LIHC	Male	All	+0.522	.003	4	view →
LUSC	All	All	+0.719	<.001	3	view →
HNSC	All	All	+0.523	.012	3	view →
CHOL	All	All	+0.975	.002	2	view →
STAD	All	All	+0.792	.041	2	view →
PRAD	All	All	+0.375	.011	2	view →
LUSC	Male	III,IV	−0.830	.049	1	view →
THCA	Male	III,IV	−0.571	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CXADR–KICH

Open the KICH breakdown →