CXADR

Across TCGA patient cohorts, CXADR mutation is significantly associated with the RNA expression of many other genes, with 1,837 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXADR-associated genes across cancer lineages are ATP5MC1, PKN3, and CCDC51. Each is linked with CXADR in more than 1 cancer types. Because this analysis shows association rather than direction, both CXADR-to-partner and partner-to-CXADR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MC1 grouped by CXADR-low versus CXADR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXADR→partner) and Y-score (partner→CXADR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5MC1 →	+0.415	+3.480	.001	.002	3	2
UCEC	PKN3 →	+0.643	+1.747	<.001	.004	3	2
UCEC	CCDC51 →	+0.493	+2.459	.001	<.001	3	2
UCEC	SMIM4 →	+0.502	+2.113	<.001	.001	3	2
UCEC	ELP5 →	+0.527	+4.311	<.001	<.001	3	2
UCEC	LSM3 →	+0.419	+2.158	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,837 associations by consensus.

ATP5MC1 by CXADR expression — UCEC

Explore this box plot interactively →