CXADR

Across TCGA pan-cancer cohorts, CXADR Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CXADR data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CXADR Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CXADR expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, READ, and SKCM are the cancer types where CXADR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.093	0.880	<.001	24	view →
READ	OS	Median	All	0.166	0.830	<.001	18	view →
SKCM	DFS	Median	All	0.318	0.767	<.001	18	view →
LUSC	OS	Median	All	0.164	0.776	.002	12	view →
GBM	OS	Median	All	0.058	0.416	<.001	6	view →
UCEC	DFS	Median	All	0.947	0.628	.032	4	view →
SARC	DFS	Median	All	0.130	0.632	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CXADR–BRCA (DFS)

Open the BRCA breakdown →