Q-omics provides the consensus-scored COPS7B profile across patient tissues and cancer cell-line models. COPS7B expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, COPS7B is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, COPS7B RNA expression shows 19,963 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and COAD as cancer lineages where COPS7B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COPS7B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COPS7B survival associations across molecular data types. COPS7B RNA expression shows survival associations in the most cancer types (24), followed by mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COPS7B RNA expression–survival associations across cancer types. High COPS7B expression shows unfavorable associations in ACC, KIRC, MESO, LIHC and KIRP, but favorable associations in HNSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for COPS7B RNA expression.
This table summarizes COPS7B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 3. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for COPS7B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COPS7B shows higher tumor expression in COAD, HNSC, LUAD, LIHC, KIRP and LUSC. The COAD box plot shows higher COPS7B RNA expression in tumor versus normal tissue (log2 FC = +1.089, t-test p < 0.001).
This table shows molecular features associated with COPS7B in patient tissues and cancer cell lines. In patient samples, COPS7B shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, COPS7B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
