COPS7B

Across TCGA patient cohorts, COPS7B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS7B-associated genes across cancer lineages are PR, Tuberin_pT1462, and ATM. Each is linked with COPS7B in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS7B-to-partner and partner-to-COPS7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PR grouped by COPS7B-low versus COPS7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS7B→partner) and Y-score (partner→COPS7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PR →	+0.289	+3.584	.017	.002	3	1
UCEC	Tuberin_pT1462 →	+0.249	+2.459	.025	.020	3	1
UCEC	ATM →	-0.594	-3.000	.006	.036	3	1
UCEC	MEK1 →	+0.448	+3.169	.011	.019	2	1
UCEC	Caspase-8 →	-0.270	-2.321	.026	.034	2	1
UCEC	JNK2 →	+0.357	+2.459	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PR by COPS7B expression — UCEC

Explore this box plot interactively →