COPS7B

Across TCGA pan-cancer cohorts, COPS7B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS7B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher COPS7B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COPS7B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

GBM, LUAD, and HNSC are the cancer types where COPS7B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.361	0.624	.002	12	view →
LUAD	OS	Quartile	III,IV	0.364	0.925	.019	10	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	4	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →
PDAC	DFS	Tertile	All	0.844	0.655	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS7B–GBM (OS)

Open the GBM breakdown →