Q-omics provides the consensus-scored COASY profile across patient tissues and cancer cell-line models. COASY expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, COASY is differentially expressed in 17, with the highest sampling consensus in BLCA. Additionally, COASY protein abundance shows 19,809 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight LIHC, BLCA, and LSCC as cancer lineages where COASY shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COASY — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COASY survival associations across molecular data types. COASY RNA expression shows survival associations in the most cancer types (23), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COASY RNA expression–survival associations across cancer types. High COASY expression shows unfavorable associations in LIHC, KIRC, ACC and UVM, but favorable associations in UCEC and BRCA. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for COASY RNA expression.
This table summarizes COASY tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for COASY. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COASY shows higher tumor expression in BLCA, HNSC, KIRP, COAD, LIHC and LUAD. The BLCA box plot shows higher COASY RNA expression in tumor versus normal tissue (log2 FC = +1.172, t-test p < 0.001).
This table shows molecular features associated with COASY in patient tissues and cancer cell lines. In patient samples, COASY shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, COASY RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SKIN and UPPER_AERODIGESTIVE_TRACT.
