COASY

Across TCGA patient cohorts, COASY protein abundance is significantly associated with the RNA expression of many other genes, with 15,269 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COASY-associated genes across cancer lineages are ARHGAP22, SLC43A3, and PPP1R18. Each is linked with COASY in more than 4 cancer types. Because this analysis shows association rather than direction, both COASY-to-partner and partner-to-COASY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COASY versus ARHGAP22 in BRCA, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COASY→partner) and Y-score (partner→COASY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP22 →	-0.559	-0.493	<.001	<.001	3	5
COAD	SLC43A3 →	-0.838	-0.327	<.001	<.001	3	5
COAD	PPP1R18 →	-0.783	-0.314	<.001	<.001	3	5
COAD	THY1 →	-0.744	-0.346	<.001	<.001	3	5
COAD	VIM →	-0.814	-0.332	<.001	<.001	3	5
BRCA	TOM1L1 →	+0.675	+0.422	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,269 associations by consensus.

COASY vs ARHGAP22 — BRCA

Explore this scatter interactively →