COASY

Across TCGA pan-cancer cohorts, COASY Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COASY data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher COASY Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COASY expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

READ, LUSC, and BLCA are the cancer types where COASY Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	II,III,IV	0.082	0.800	<.001	12	view →
LUSC	OS	Median	III,IV	0.047	0.684	<.001	12	view →
BLCA	DFS	Median	III,IV	1.000	0.274	.042	10	view →
BRCA	DFS	Median	II,III,IV	0.708	0.942	<.001	6	view →
UCEC	DFS	Median	All	0.968	0.830	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COASY–READ (DFS)

Open the READ breakdown →