COASY

Across TCGA pan-cancer cohorts, COASY mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COASY data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COASY mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COASY expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where COASY mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.918	.012	36	view →
CCRCC	DFS	Median	All	1.000	0.513	<.001	27	view →
LSCC	OS	Median	III,IV	0.744	0.949	.015	4	view →
PDAC	OS	Median	All	0.768	0.909	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COASY–COAD (DFS)

Open the COAD breakdown →