COASY

Across TCGA patient cohorts, COASY mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COASY-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MEK1. Each is linked with COASY in more than 1 cancer types. Because this analysis shows association rather than direction, both COASY-to-partner and partner-to-COASY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by COASY-low versus COASY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COASY→partner) and Y-score (partner→COASY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.294	-2.584	.002	.001	3	2
UCEC	JNK2 →	+0.263	+2.584	<.001	.001	3	2
UCEC	MEK1 →	+0.370	+2.584	.008	.001	3	2
UCEC	PDCD4 →	-0.443	-3.169	.014	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.968	+2.242	<.001	.005	3	2
UCEC	eIF4E →	+0.208	+3.584	.010	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by COASY expression — UCEC

Explore this box plot interactively →