COASY

Across TCGA patient cohorts, COASY RNA expression is significantly associated with the protein abundance of many other proteins, with 16,278 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COASY-associated proteins across cancer lineages are LIG3, THOC6, and DNAJC7. Each is linked with COASY in more than 6 cancer types. Because this analysis shows association rather than direction, both COASY-to-partner and partner-to-COASY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COASY versus LIG3 in LSCC, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COASY→partner) and Y-score (partner→COASY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LIG3 →	+0.419	+0.565	<.001	<.001	3	7
LSCC	THOC6 →	+0.211	+0.433	<.001	<.001	3	6
OV	DNAJC7 →	+0.345	+0.391	.003	.004	3	6
LSCC	SUPT6H →	+0.256	+0.588	<.001	<.001	3	6
LSCC	THOC2 →	+0.240	+0.470	<.001	<.001	3	5
GBM	THOC5 →	+0.238	+0.212	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,278 associations by consensus.

COASY vs LIG3 — LSCC

Explore this scatter interactively →