CNKSR family member 3Genealiases: CNK3 · CNK3/IPCEF1 · MAGI1
Q-omics provides the consensus-scored CNKSR3 profile across patient tissues and cancer cell-line models. CNKSR3 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CNKSR3 is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, CNKSR3 RNA expression shows 19,721 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, KICH, and THYM as cancer lineages where CNKSR3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CNKSR3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CNKSR3 survival associations across molecular data types. CNKSR3 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CNKSR3 RNA expression–survival associations across cancer types. High CNKSR3 expression shows unfavorable associations in STAD and LGG, but favorable associations in KIRC, HNSC, READ and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for CNKSR3 RNA expression.
This table summarizes CNKSR3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for CNKSR3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CNKSR3 shows lower tumor expression in KICH, BLCA, THCA, COAD and PAAD and higher tumor expression in KIRC. The KICH box plot shows higher CNKSR3 RNA expression in normal versus tumor tissue (log2 FC = −2.813, t-test p < 0.001).
This table shows molecular features associated with CNKSR3 in patient tissues and cancer cell lines. In patient samples, CNKSR3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, CNKSR3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
