CNKSR3

Across TCGA cell cohorts, CNKSR3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNKSR3-associated genes across cancer lineages are NKX2-6, TLE7, and UBE2QL1. Each is linked with CNKSR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR3-to-partner and partner-to-CNKSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by CNKSR3-low versus CNKSR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR3→partner) and Y-score (partner→CNKSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.258	+3.766	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NKX2-6 by CNKSR3 expression — BLOOD_Leukemia

Explore this box plot interactively →