CNKSR3

Across TCGA patient cohorts, CNKSR3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR3-associated genes across cancer lineages are MEK1, A-Raf_pS299, and FASN. Each is linked with CNKSR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR3-to-partner and partner-to-CNKSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CNKSR3-low versus CNKSR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR3→partner) and Y-score (partner→CNKSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.544	+3.584	<.001	.002	3	2
UCEC	A-Raf_pS299 →	-0.108	-3.169	.044	.019	3	1
UCEC	FASN →	+0.373	+2.000	.036	.032	3	1
UCEC	Gab2 →	+0.402	+2.700	.012	.006	3	1
UCEC	ACC1 →	+0.382	+2.000	.019	.032	3	1
UCEC	Notch1 →	+0.195	+2.469	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MEK1 by CNKSR3 expression — UCEC

Explore this box plot interactively →