CNKSR3

Across TCGA pan-cancer cohorts, CNKSR3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CNKSR3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CNKSR3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNKSR3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where CNKSR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.547	0.967	<.001	21	view →
PDAC	OS	Median	All	0.299	0.827	.024	12	view →
LSCC	DFS	Tertile	II,III,IV	0.807	0.315	.005	9	view →
UCEC	DFS	Median	All	0.982	0.830	.020	8	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.815	.046	2	view →
LUAD	OS	Median	All	0.908	0.344	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CNKSR3–HNSC (DFS)

Open the HNSC breakdown →