CNKSR3

Across TCGA patient cohorts, CNKSR3 mutation is significantly associated with the RNA expression of many other genes, with 1,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR3-associated genes across cancer lineages are MIR4291, RN7SKP291, and RNA5SP358. Each is linked with CNKSR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR3-to-partner and partner-to-CNKSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4291 grouped by CNKSR3-low versus CNKSR3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR3→partner) and Y-score (partner→CNKSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4291 →	+0.231	+7.473	<.001	.007	3	2
HNSC	RN7SKP291 →	+0.118	+4.286	<.001	.007	3	2
HNSC	RNA5SP358 →	+0.195	+4.146	<.001	.008	3	2
HNSC	IGHD2-15 →	+1.379	+4.489	<.001	<.001	3	2
COAD	OR9Q2 →	+0.047	+4.721	<.001	.004	3	2
COAD	RPL35AP30 →	+0.243	+3.541	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,508 associations by consensus.

MIR4291 by CNKSR3 expression — BRCA

Explore this box plot interactively →