connector enhancer of kinase suppressor of Ras 1Genealiases: CNK · CNK1
Q-omics provides the consensus-scored CNKSR1 profile across patient tissues and cancer cell-line models. CNKSR1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, CNKSR1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, CNKSR1 RNA expression shows 16,257 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, KIRC, and THYM as cancer lineages where CNKSR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CNKSR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CNKSR1 survival associations across molecular data types. CNKSR1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CNKSR1 RNA expression–survival associations across cancer types. High CNKSR1 expression shows unfavorable associations in ACC, KIRP and LUSC, but favorable associations in BLCA, LUAD and SKCM. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for CNKSR1 RNA expression.
This table summarizes CNKSR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for CNKSR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CNKSR1 shows lower tumor expression in KIRC, KIRP and KICH and higher tumor expression in BLCA, LUAD and UCEC. The KIRC box plot shows higher CNKSR1 RNA expression in normal versus tumor tissue (log2 FC = −2.881, t-test p < 0.001).
This table shows molecular features associated with CNKSR1 in patient tissues and cancer cell lines. In patient samples, CNKSR1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, CNKSR1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in CNS and BLOOD_Leukemia.
