CNKSR1

Across TCGA cell cohorts, CNKSR1 mutation is significantly associated with the RNA expression of many other genes, with 157 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNKSR1-associated genes across cancer lineages are IMPG1, RASGRF2, and ASB3. Each is linked with CNKSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR1-to-partner and partner-to-CNKSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMPG1 grouped by CNKSR1-low versus CNKSR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR1→partner) and Y-score (partner→CNKSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IMPG1 →	+0.090	+4.120	<.001	<.001	3	1
BLOOD_Leukemia	RASGRF2 →	+0.205	+3.259	<.001	.006	3	1
BLOOD_Leukemia	ASB3 →	+0.554	+3.199	.001	.007	3	1
BLOOD_Leukemia	RPA2 →	+0.475	+3.199	.001	.007	3	1
BLOOD_Leukemia	ALDH8A1 →	+0.721	+3.199	<.001	.007	3	1
BLOOD_Leukemia	SNRNP27 →	+0.500	+3.199	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 157 associations by consensus.

IMPG1 by CNKSR1 expression — BLOOD_Leukemia

Explore this box plot interactively →