CNKSR1

Across TCGA patient cohorts, CNKSR1 mutation is significantly associated with the RNA expression of many other genes, with 2,756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR1-associated genes across cancer lineages are PSMC3IP, SLC35F6, and OR6C5P. Each is linked with CNKSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNKSR1-to-partner and partner-to-CNKSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by CNKSR1-low versus CNKSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR1→partner) and Y-score (partner→CNKSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.578	+3.928	<.001	<.001	3	3
UCEC	SLC35F6 →	+0.502	+1.970	<.001	<.001	3	3
GBM	OR6C5P →	+0.101	+6.189	<.001	.001	3	2
UCEC	LACTB →	+0.486	+3.119	<.001	<.001	3	2
UCEC	PSMD9 →	+0.316	+1.781	.004	.008	2	3
SKCM	ACTR1A →	+0.310	+1.855	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,756 associations by consensus.

PSMC3IP by CNKSR1 expression — UCEC

Explore this box plot interactively →