CNKSR1

Across TCGA cell cohorts, CNKSR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,482 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CNKSR1-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Response to indole-3-methanol, and Activation of GTPase activity. Each is linked with CNKSR1 in more than 11 cancer types. Because this analysis shows association rather than direction, both CNKSR1-to-partner and partner-to-CNKSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by CNKSR1-low versus CNKSR1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR1→partner) and Y-score (partner→CNKSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.214	+1.993	.001	.002	3	12
PANCREAS	Response to indole-3-methanol →	+0.243	+2.220	<.001	<.001	3	12
LUNG_SCLC	Activation of GTPase activity →	+0.119	+1.144	.001	.004	3	12
STOMACH	Negative regulation of actin filament bundle assembly →	+0.139	+2.408	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of ventricular cardiac muscle cell action potential →	+0.235	+1.889	.007	.004	2	12
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.213	+1.638	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,482 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by CNKSR1 expression — OESOPHAGUS

Explore this box plot interactively →