CNKSR1

Across TCGA patient cohorts, CNKSR1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR1-associated genes across cancer lineages are 14-3-3_beta, Akt_pT308, and ATM. Each is linked with CNKSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR1-to-partner and partner-to-CNKSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CNKSR1-low versus CNKSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR1→partner) and Y-score (partner→CNKSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.086	-2.432	.013	.018	3	2
UCEC	Akt_pT308 →	+0.521	+1.440	.017	.024	3	2
UCEC	ATM →	-0.613	-2.893	<.001	.001	3	2
UCEC	eIF4E →	+0.154	+2.472	.035	.010	3	1
UCEC	A-Raf_pS299 →	-0.100	-2.000	.015	.030	3	1
UCEC	GAPDH →	+0.369	+2.321	.047	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

14-3-3_beta by CNKSR1 expression — UCEC

Explore this box plot interactively →