cellular communication network factor 5Genealiases: CT58 · CTGF-L · WISP2
Q-omics provides the consensus-scored CCN5 profile across patient tissues and cancer cell-line models. CCN5 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, CCN5 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, CCN5 protein abundance shows 21,148 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRP, COAD, and LUAD as cancer lineages where CCN5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CCN5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CCN5 survival associations across molecular data types. CCN5 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (9) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CCN5 RNA expression–survival associations across cancer types. High CCN5 expression shows unfavorable associations in KIRP, KIRC and OV, but favorable associations in UVM, ESCA and ACC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for CCN5 RNA expression.
This table summarizes CCN5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in COAD for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CCN5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CCN5 shows lower tumor expression in COAD, LUSC, STAD, LUAD and BLCA and higher tumor expression in KIRC. The COAD box plot shows higher CCN5 RNA expression in normal versus tumor tissue (log2 FC = −2.512, t-test p < 0.001).
This table shows molecular features associated with CCN5 in patient tissues and cancer cell lines. In patient samples, CCN5 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, CCN5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and BONE.
