CCN5

Across TCGA patient cohorts, CCN5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCN5-associated genes across cancer lineages are ATM, MSH6, and p62 Lck ligand. Each is linked with CCN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN5-to-partner and partner-to-CCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCN5-low versus CCN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN5→partner) and Y-score (partner→CCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.576	-2.584	.006	.011	3	2
UCEC	MSH6 →	-0.401	-2.999	.009	.035	3	1
UCEC	p62 Lck ligand →	+0.383	+2.179	.011	.034	3	1
UCEC	PRDX1 →	+0.218	+3.169	.023	.019	3	1
UCEC	Annexin-1 →	+0.542	+2.827	.027	.035	3	1
UCEC	c-Met_pY1235 →	+0.083	+2.179	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by CCN5 expression — UCEC

Explore this box plot interactively →