CCN5

Across TCGA cell cohorts, CCN5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCN5-associated genes across cancer lineages are MAGEB5, SLC5A7, and USP29. Each is linked with CCN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN5-to-partner and partner-to-CCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CCN5-low versus CCN5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN5→partner) and Y-score (partner→CCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ALPI →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR7G2 →	+0.032	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR5M1 →	+0.020	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MAGEB5 by CCN5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →