CCN5

Across TCGA cell cohorts, CCN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,956 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCN5-associated GO terms across cancer lineages are Regulation of centriole-centriole cohesion, Autophagosome assembly, and Process utilizing autophagic mechanism. Each is linked with CCN5 in more than 8 cancer types. Because this analysis shows association rather than direction, both CCN5-to-partner and partner-to-CCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole-centriole cohesion grouped by CCN5-low versus CCN5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN5→partner) and Y-score (partner→CCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of centriole-centriole cohesion →	+0.116	+0.158	<.001	<.001	3	8
BLOOD_Leukemia	Autophagosome assembly →	+0.037	+0.131	<.001	.001	3	8
STOMACH	Process utilizing autophagic mechanism →	+0.066	+0.370	.003	.001	2	9
STOMACH	Autophagy →	+0.066	+0.370	.003	.001	2	9
LUNG_NSCLC_LUAD	Vacuolar transport →	+0.037	+1.858	.001	.005	3	8
OVARY	Response to temperature stimulus →	+0.035	+1.071	.005	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,956 associations by consensus.

Regulation of centriole-centriole cohesion by CCN5 expression — BLOOD_Leukemia

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