calcium sensing receptorGenealiases: CAR · EIG8 · FHH · FIH · GPRC2A · HHC
Q-omics provides the consensus-scored CASR profile across patient tissues and cancer cell-line models. CASR expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CASR is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, CASR RNA expression shows 10,339 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight HNSC, KIRC, and LUAD as cancer lineages where CASR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CASR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CASR survival associations across molecular data types. CASR RNA expression shows survival associations in the most cancer types (20), followed by mutation status (8) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CASR RNA expression–survival associations across cancer types. High CASR expression shows unfavorable associations in SCLC and ACC, but favorable associations in HNSC, KIRC, CESC and BLCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for CASR RNA expression.
This table summarizes CASR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for CASR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CASR shows lower tumor expression in KIRC, KIRP, KICH, COAD, READ and LIHC. The KIRC box plot shows higher CASR RNA expression in normal versus tumor tissue (log2 FC = −5.285, t-test p < 0.001).
This table shows molecular features associated with CASR in patient tissues and cancer cell lines. In patient samples, CASR shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, CASR RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
