CASR

Across TCGA pan-cancer cohorts, CASR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CASR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CASR RNA is repressed in tumor relative to normal tissue. In most cancer types CASR is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where CASR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−5.285	<.001	12	view →
KIRP	Female	II,III,IV	−5.438	<.001	11	view →
KICH	Male	IV	−5.540	<.001	10	view →
COAD	Female	II,III,IV	−0.378	<.001	10	view →
READ	All	All	−0.352	<.001	3	view →
LIHC	Male	III,IV	−0.227	.015	3	view →
ESCA	All	II,III,IV	+0.950	.037	2	view →
UCEC	All	IV	−0.545	.029	2	view →
STAD	All	All	−0.306	.020	2	view →
LUAD	Female	III,IV	−0.166	.004	2	view →
PRAD	All	All	−0.041	.001	2	view →
THCA	All	II,III,IV	−0.130	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CASR–KIRC

Open the KIRC breakdown →