CASR

Across TCGA cell cohorts, CASR RNA expression is significantly associated with the go_rna of many other GO terms, with 113 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CASR-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Magnesium ion homeostasis, and Regulation of collagen metabolic process. Each is linked with CASR in more than 2 cancer types. Because this analysis shows association rather than direction, both CASR-to-partner and partner-to-CASR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by CASR-low versus CASR-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASR→partner) and Y-score (partner→CASR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Termination of RNA polymerase II transcription →	+0.083	+0.010	<.001	.002	3	3
LARGE_INTESTINE	Magnesium ion homeostasis →	+0.063	+0.007	.006	.006	3	3
BLOOD_Lymphoma	Regulation of collagen metabolic process →	-0.073	-0.082	.001	.009	3	3
LARGE_INTESTINE	Negative regulation of amine metabolic process →	-0.146	-0.007	.002	.004	3	2
LARGE_INTESTINE	Positive regulation of respiratory burst →	-0.207	-0.013	<.001	.005	3	2
LARGE_INTESTINE	Peripheral nervous system axon regeneration →	-0.185	-0.007	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

Termination of RNA polymerase II transcription by CASR expression — LARGE_INTESTINE

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