CASR

Across TCGA patient cohorts, CASR protein abundance is significantly associated with the RNA expression of many other genes, with 1,068 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CASR-associated genes across cancer lineages are BSPRY, GGT6, and MIR148A. Each is linked with CASR in more than 1 cancer types. Because this analysis shows association rather than direction, both CASR-to-partner and partner-to-CASR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASR versus BSPRY in CCRCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASR→partner) and Y-score (partner→CASR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BSPRY →	+1.018	+0.335	.001	.006	3	2
PDAC	GGT6 →	+0.869	+0.408	<.001	.008	3	2
LUAD	MIR148A →	+0.963	+1.841	<.001	<.001	3	2
PDAC	SIM1-AS1 →	+0.889	+0.652	<.001	.003	3	2
PDAC	F11 →	+1.168	+0.475	<.001	.001	3	2
PDAC	ESS2 →	-0.182	-0.455	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,068 associations by consensus.

CASR vs BSPRY — CCRCC

Explore this scatter interactively →