CASR

Across TCGA patient cohorts, CASR mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASR-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and Cyclin-E2. Each is linked with CASR in more than 4 cancer types. Because this analysis shows association rather than direction, both CASR-to-partner and partner-to-CASR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CASR-low versus CASR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASR→partner) and Y-score (partner→CASR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.561	+1.663	<.001	.001	3	5
STAD	Caveolin-1 →	-1.212	-3.000	.001	.036	3	3
STAD	Cyclin-E2 →	+0.266	+3.021	<.001	.017	3	3
COAD	MIG-6 →	+0.110	+3.229	.023	.009	3	3
COAD	ASNS →	+0.575	+3.178	.003	.010	3	3
UCEC	eIF4E →	+0.150	+1.494	.010	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Caspase-7-cleavedD198 by CASR expression — UCEC

Explore this box plot interactively →