calcium/calmodulin dependent protein kinase II alphaGenealiases: CAMKA · CaMKIINalpha · CaMKIIalpha · MRD53 · MRT63
Q-omics provides the consensus-scored CAMK2A profile across patient tissues and cancer cell-line models. CAMK2A expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CAMK2A is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, CAMK2A RNA expression shows 22,368 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, KIRC, and GBM as cancer lineages where CAMK2A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CAMK2A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CAMK2A survival associations across molecular data types. CAMK2A RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CAMK2A RNA expression–survival associations across cancer types. High CAMK2A expression shows unfavorable associations in UVM, MESO, HNSC, KIRC and BLCA, but favorable associations in ACC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for CAMK2A RNA expression.
This table summarizes CAMK2A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CAMK2A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CAMK2A shows lower tumor expression in KIRC, BLCA, KIRP, LUAD, COAD and KICH. The KIRC box plot shows higher CAMK2A RNA expression in normal versus tumor tissue (log2 FC = −0.832, t-test p < 0.001).
This table shows molecular features associated with CAMK2A in patient tissues and cancer cell lines. In patient samples, CAMK2A shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, CAMK2A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
