CAMK2A

Across TCGA patient cohorts, CAMK2A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAMK2A-associated genes across cancer lineages are Notch1, P-Cadherin, and RBM15. Each is linked with CAMK2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMK2A-to-partner and partner-to-CAMK2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CAMK2A-low versus CAMK2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMK2A→partner) and Y-score (partner→CAMK2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.161	+3.598	<.001	.001	3	2
UCEC	P-Cadherin →	-0.126	-3.459	.011	.005	3	2
UCEC	RBM15 →	+0.249	+2.083	.024	.001	3	2
UCEC	ATM →	-0.448	-1.440	.004	.024	3	2
UCEC	C-Raf →	+0.154	+2.070	.001	.001	3	2
UCEC	14-3-3_beta →	-0.104	-3.780	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Notch1 by CAMK2A expression — UCEC

Explore this box plot interactively →