CAMK2A

Across TCGA cell cohorts, CAMK2A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAMK2A-associated genes across cancer lineages are KLHL40, TBC1D3H, and ITGAD. Each is linked with CAMK2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMK2A-to-partner and partner-to-CAMK2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by CAMK2A-low versus CAMK2A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMK2A→partner) and Y-score (partner→CAMK2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
SKIN	TBC1D3H →	+0.673	+4.510	<.001	.001	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.025	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KLHL40 by CAMK2A expression — BLOOD_Lymphoma

Explore this box plot interactively →