CAMK2A

Across TCGA cell cohorts, CAMK2A mutation is significantly associated with the mutation status of many other genes, with 1,379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAMK2A-associated genes across cancer lineages are PDE1B, GSE1, and FBL. Each is linked with CAMK2A in more than 3 cancer types. Because this analysis shows association rather than direction, both CAMK2A-to-partner and partner-to-CAMK2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE1B grouped by CAMK2A-low versus CAMK2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMK2A→partner) and Y-score (partner→CAMK2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDE1B →	+3.422	+4.807	<.001	<.001	1	4
SKIN	GSE1 →	+3.053	+3.718	.006	.006	1	3
BLOOD_Lymphoma	FBL →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	LOXL3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	KCNQ4 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	ZNF365 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,379 associations by consensus.

PDE1B by CAMK2A expression — LARGE_INTESTINE

Explore this box plot interactively →